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General Health | Acne

Differin Gel

Prescription Only Medication (POM)

Differin is a topical treatment used for mild to moderate acne. It is in the class of medication known as retinoids.

Differin Gel
Image for illustration purposes only.

Frequently Asked Questions

What is Differin Gel?

The active ingredient in Differin is called Adapalene. Differin has an anti-inflammatory effect reducing soreness and irritation. You can buy Differin Gel to treat mild to moderate acne on the face, chest, or back for acne, where the skin may have lots of blackheads, spots, and pimples.

Differin increases the turnover of skin cells keeping pores clear. As acne spots and pimples are often caused by pore blockages getting infected, Differin reduces the occurrence of spots and pimples.

Differin Gel can take up to four to six weeks before you see noticeable results. It should NOT be used for more than 3 months consecutively. The effectiveness of the treatment can vary from patient to patient. If you don’t feel like Differin is working for you after six weeks, speak to your healthcare professional about alternatives.

How do you use Differin Gel?

Whenever you buy Differin Gel online, or from your local GP, always use the medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. 

  • Differin is only intended for use in adults and adolescents aged 12 years and over. 
  • This medicine is for EXTERNAL USE ONLY. 
  • Differin is applied at night before going to bed, unless your doctor has told you otherwise. 
  • Thoroughly wash the areas to be treated with water. Make sure the skin is clean and dry before using this medicine. 
  • Put a thin film of the cream with your fingertips onto the affected areas and rub in gently. 
  • Do not forget to wash your hands afterwards. 
  • How long you will have to use this medicine will depend on how quickly your acne improves. After you have used this medicine for 3 months, you must see your doctor. He or she can then check the improvement of your acne. 

Side effects of Differin Gel?

All medicines have the potential to cause side effects. The most common side effects of Differin:

  • dry skin
  • irritation of the skin
  • burning sensation of the skin
  • redness of the skin

These typically go away with use as your skin becomes accustomed to the medication. Uncommon side effects of Differin include:

  • local skin reactions (contact dermatitis)
  • skin discomfort
  • sunburn
  • itching of the skin (pruritus)
  • peeling skin (exfoliation)
  • flare-up of acne

You can find out more about Differin Gel online in the Differin Gel patient information leaflet.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

What is Acne?

Acne is a common skin condition that affects most people at some point. It causes spots, oily skin, and sometimes skin that’s hot or painful to touch. Acne commonly develops on the face, chest, and back. Acne is commonly linked to a change in hormone levels which can happen in puberty and menstrual cycles, as well as to genetic factors.

There is not always a known cause for Acne, but it is very common and affects around 95% of people aged 11-30 to some extent. For mild to moderate Acne often a pharmacist will be able to offer you creams and treatments that can help reduce acne pimples.

Other information on the causes of acne can be read about on the NHS website.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

How else can you prevent Acne?

Before you buy Differin Gel online please read the ways that are recommended to prevent acne flare-ups:

  • Not washing the affected area more than twice a day
  • Use a mild soap or cleanser and lukewarm water
  • Do not try to “clean out” blackheads or squeeze spots. This can make them worse and cause permanent scarring.
  • Avoid using too much make-up and cosmetics. Use water-based products that are described as non-comedogenic.
  • Completely remove make-up before going to bed.
  • If dry skin is a problem, use a fragrance-free water-based emollient.
  • Regular exercise cannot improve your acne, but it can boost your mood and improve your self-esteem. Shower as soon as possible once you finish exercising as sweat can irritate your acne.
  • Wash your hair regularly and try to avoid letting your hair fall across your face

Due to the recent complications of the coronavirus, it is possible your acne might be flaring up. Read our blog article; ‘Acne in quarantine: 7 reasons your skin is breaking out at home’ to learn more.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

Differin Gel interactions with alcohol and food?

Alcohol dries out the skin so it is best to limit intake when you buy Differin Gel and commence the course of treatment. 

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

Differin Gel interactions with other drugs?

If you buy Differin Gel it will not interact with any drugs.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

Are there any reason why you would not be able to take Differin Gel?

Do not use Differin Gel:

  • If you are pregnant
  • Children under the age of 12
  • If you are planning a pregnancy
  • If you are allergic to adapalene or any of the other ingredients of this medicine

If you choose to buy Differin gel online from e-Surgery, one of our prescribers will make sure the medication is suitable for you to use.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

Why should you buy Differin Gel?

When you buy Differin Gel it will act as an anti-inflammatory decreasing the appearance of acne on the skin.  Acne can decrease self-confidence so when you buy Differin Gel online, or from your local GP, it can improve this! It is important to remember,

  • Acne is very common in teenagers and younger adults. About 95% of people aged 11 to 30 are affected by acne to some extent.
  • Acne is most common in girls from the ages of 14 to 17, and in boys from the ages of 16 to 19.
  • Most people have acne on and off for several years before their symptoms start to improve as they get older.
  • Acne often disappears when a person is in their mid-20s.
  • In some cases, acne can continue into adult life. About 3% of adults have acne over the age of 35.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

Can you buy Differin Gel online?

Yes, you can legally buy Differin Gel online from registered online prescribers such as e-Surgery.

Whenever you buy Differin Gel or any other medication, make sure you check for the green GPhC logo on the bottom of each page of the website you are using.

You can use the GPhC website to check if a pharmacy is registered, this will ensure that when you buy Differin Gel online it will be genuine.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

Where can you learn more about Differin Gel online?

You can learn more about this Differin Gel online in the Patient Information Leaflet, which contains more useful information.

You can also use our completely free Ask-a-Pharmacist service to get health advice from a trained professional. We’re here to help!

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

If you buy Differin Gel online, how much will it cost?

If you choose to buy Differin Gel online from e-Surgery prices start at £24.95. This includes the cost of private prescription.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

How do you store Differin Gel?

Do not store Differin above 25°C and do not freeze. Store the closed Differin tube away from direct heat as per instruction of the patient information leaflet. 

Do not use Differin after the expiry date which is stated on the tube and carton. Whenever you buy Differin Gel online, or any other medication, please check the expiry date when it arrives to you in the post.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

If you buy Differin Gel online, how will it be delivered?

e-Surgery uses Royal Mail delivery with choices starting from; Royal Mail 48 tracked delivery, Royal Mail tracked 24 and Royal Mail 1 pm special delivery. (discover more about e-Surgery delivery). When you buy Differin Gel it will arrive in discreet, recyclable packaging at a delivery address of your choice.

Find out more if you are unsure how to recycle our packaging.

Differin Gel is a medicine used to inhibit acne. However, we advise that our customers consult their doctors or prescribers before using or buying Differin Gel online.

What are retinoids, and why are they important when clearing acne?

The retinoids in Differin Gel make sure your skin goes through the correct process, which creates a healthier environment for your skin. The retinoids in Differin Gel also regulate skin cell turnover which helps to stop pores from clogging. It can also prevent acne from starting.  

However, we cannot guarantee that everyone will have the same experience when using Differin Gel as everyone’s skin is different. 

Customers should seek advice from their doctor or prescriber to discuss treatment options or before they buy Differin to make sure they get the best care treatment for their skin.

Can you use Differin Gel when pregnant?

It is recommended that you stop using Differin Gel when pregnant until you have consulted your doctor. 

Customers should seek advice from their doctor or prescriber to discuss treatment options or before they buy Differin to make sure they get the best care treatment for their skin.

How should I dispose of Differin Gel?

You should not dispose of the Differin Gel container in the general waste bin once you have finished using the item or if it has expired and is no longer usable. Please return it to your local pharmacy or GP surgery for the correct disposal.  

Customers should seek advice from their doctor or prescriber to discuss treatment options or before they buy Differin to make sure they get the best care treatment for their skin.

Can you stop using Differin Gel once your acne clears up?

It is important that you continue to use Differin Gel even after your skin looks clearer to inhibit further breakouts. 

Customers should always seek advice from their doctor or prescriber to discuss treatment options or before they buy Differin to make sure they get the best care treatment for their skin.

Which is better, Differin Gel or Aknemycin Plus?

It is dependent on the patient and a range of other factors as to whether Differin Gel or Aknemycin Plus will prove to be more effective.  

Customers should seek advice from their doctor or prescriber to discuss treatment options or before they buy Differin to make sure they get the best care treatment for their skin.

Which is better, Differin Gel or Epiduo Gel?

It is dependent on the patient and a range of other factors as to whether Differin Gel or Epiduo Gel will prove to be more effective.  

Customers should seek advice from their doctor or prescriber to discuss treatment options or before they buy Differin to make sure they get the best care treatment for their skin. 

Which is better, Differin Gel or Lymecycline?

It is dependent on the patient and a range of other factors as to whether Differin Gel or Lymecycline will prove to be more effective.  

Customers should seek advice from their doctor or prescriber to discuss treatment options or before they buy Differin to make sure they get the best care treatment for their skin.

What Our Patients Say

Our patient care team is excellent!

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Excellent customer service, when I need a medicine they provide me on time , I really like their service, thank you so much.
J
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easy to apply, no scent, no sting
A
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Really helped my skin clear up, haven't used it for a few months and skin is getting worse so i will be going back to it.
L
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Great product, although takes time to see results
A
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Great product
A
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The best i love this product
A
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Perfect if you’re struggling with persistent acne on face & body!
A
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Works well after a period of time although over applying does cause very dry itchy skin
M
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The only thing that has ever worked for my acne skin.
A
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Persevere with treatment as you'll notice a big improvement after 6-8 weeks!
I
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Worth the money.
A
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Worked very well.
M
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helped so much
A
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My skin has adapted really well with differin and I see really good results
A
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Does as described
A
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really good at clearing pores
A
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Great product. Works well
A
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Really helped my acne although I do still need to go up a percentage to clear my skin fully. My scaring and texture is the best it's been since I developed acne around 13. Of course it's a retinoid you do experience dryness and sensitivity when you start but it was easily managed by just mixing a few drops of vit e oil before applying. I think I maybe had to take one or 2 days off due to dryness a week in.
E
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It helps treat spots and acne but also dries the skin
A
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Really helped with my acne. my acne initially got worse but then started to clear up and i noticed a huge difference in the texture and redness
O
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My skin looks so much clearer. And smoother
S
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No obvious effects. Acne returned.
A
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Made acne worse, more pimples than I had before and extra dry sensitive skin. Used the 45g tube for just over 8 weeks and my skin is worse than when I started.
A
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quick delivery / effective
A
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best product withazelaic acid combined
V
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Really useful and perfect for my acne
P
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I have been using Different on and off for many years to treat adult acne. According to my dermatologist, this should be a staple product in my evening routine. I have been following her advice (as well as using other cosmetic products that she recommended) and have managed to stay acne-free for a few years now. It can be tricky to get the right amount at first and it's easy to forget that with Differin less is more, but overall it's a great product. Using a gentle cleanser and a good non-comedogenic moisturizer has helped me deal with occasional skin dryness and enjoy the full benefits of Differin.
B
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Has helped reduce my acne massively
L
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Came as expected
R
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Fantastic,arrived quickly,excellent communication,will use regularly A+
A
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Doesn't irritate my sensitive skin, appears to be effective after a couple of weeks use so far.
B
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Brilliant product for clearing pores and evening out skin tone
M
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Very effective product
G
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Great product, really working well.
N
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Week 3 on Differin - yes had some dry skin, and regular spots appearing tell me skin is purging but they are healing fast and my existing spots from 3 weeks ago gone completely. I did use every night from day 1 but added in moisturiser before and after for first two weeks - my skin can now take a bit more so it goes on last thing at night.
M
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it was delivered on time
N
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Great Product
P
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Good quality
M
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Good for my skin.
S
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I saw the difference after 3 weeks of using it. Have no more redness on my face.
N
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Great product, I get good results without any complications. If this is the right product for you I would recommend without any hesitation whatsoever.
L
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No idea what this is
C
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It used to be cheaper
N
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Excellent product
L
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Effective and well tolerated when used sparingly as directed.
S
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It took some time for my skin to adapt to differing, nevertheless, I can already see improvements after using it for 1 week.
O
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Did the job as described
L
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Fast and good service
N
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Genuine product
V
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Totally as expected and described product and in a good price.
A
1 of 50 reviews
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