woman examining which is better Nitrofurantoin vs Trimethoprim | e-surgery

Exploring Nitrofurantoin vs Trimethoprim: Which is better?

Did you know that if you’re a woman, you are more likely to get a urinary tract infection? According to some doctors, a woman’s lifetime probability of developing a UTI is as high as one in two, with many women experiencing recurring infections for years. Additionally, one in every ten males will have a UTI during their lifespan. Here’s some information on UTIs, including treating them and reducing your chances of developing the condition. [1]  

What is a UTI?

A urinary tract infection (UTI) is a bacterial infection of the urinary tract. These organisms are so tiny that one cannot see them without a microscope. Bacteria cause the majority of UTIs. Urinary tract infections (UTIs) is a very common condition in humans. Most UTIs only affect the urethra and bladder in the lower tract. However, sometimes they can affect the ureters and kidneys in the upper tract. Although upper tract UTIs are less common than lower tract UTIs, they are typically more severe. [2]

Key differences: Nitrofurantoin Vs Trimethoprim

Nitrofurantoin is an effective antibiotic and has a low risk of causing bacterial resistance. It is used to treat urinary tract infections caused by susceptible bacteria. On the other hand, Trimethoprim is an antibiotic used to treat bladder or kidney infections and ear infections caused by specific bacteria. [3] Both are available online from e-Surgery for future infections if you have previously been prescribed this medication.

Why your doctor may prescribe Nitrofurantoin or Trimethoprim?

woman at the doctor wondering which is better Nitrofurantoin vs Trimethoprim | e-surgery

The treatment and dosage you receive are determined by a variety of factors, such as whether your condition is severe or uncomplicated. Your GP may wish to take a urine sample. [4] Once they have established you have a UTI they may offer self-care advice and recommend taking a pain killer in addition to antibiotics if they are required. It’s important to finish the whole course of antibiotics, even if you start to feel better, and to speak to your doctor about any concerns you may have or if your condition does not improve after treatment. If you suffer from recurrent UTIs, you may be able to order treatment ahead of time online from e-Surgery.

Symptoms and causes of a UTI

Symptoms of a UTI might include:

  • Peeing more often than usual during the night (nocturia)
  • Cloudy urine
  • Lower tummy pain or back pain under the ribs
  • High temperature, or feeling hot and shivery
  • Considerably low temperature below 36C
  • Feeling the need to pee suddenly or more urgently than normal
  • Peeing more often than usual
  • Blood in urine
  • Pain or a burning sensation while you pee (dysuria) [5]

Side effects of Nitrofurantoin & Trimethoprim


Common nitrofurantoin side effects may include:

  • Headache
  • Dizziness
  • Vaginal itching or discharge
  • Mild diarrhea
  • Gas
  • Upset stomach

Get emergency medical attention if you have any allergic reaction to nitrofurantoin or Trimethoprim and have symptoms like breathing issues, swelling of your face, lips, tongue, hives or neck. [6]


Common side effects of Trimethoprim include:

  • Vomiting
  • Diarrhoea
  • Stomach pain
  • Rash
  • Itching
  • Swollen tongue

In rare cases, individuals may develop severe symptoms, so get immediate medical attention if you experience any unusual or severe effects after taking either of the two drugs.

What is the course duration of the UTI Anti-Biotics Nitrofurantoin & Trimethoprim?

Trimethoprim dose

The standard treatment from e-Surgery consists of taking 200mg of Trimethoprim twice daily for 3 days. 

Nitrofurantoin dose

The standard treatment from e-Surgery consists of 100mg Nitrofurantoin slow-release tablets taken twice a day for 3 days.

Where can I buy Nitrofurantoin & Trimethoprim online?

You can order antibiotics such as Trimethoprim or Nitrofurantoin to treat Urinary tract infection (UTI) conveniently online via e-Surgery.


  1. Urinary Tract Infection (UTI): Symptoms, Causes, Treatment | WebMD
  2. Urinary Tract Infection: Symptoms, Diagnosis & Treatment | Healthline
  3. Nitrofurantoin vs Trimethoprim Comparison | Drugs.com
  4. Treatment for Urinary Tract Infections: Antibiotics & More | WebMD
  5. Urinary tract infections (UTIs) – NHS | NHS
  6. Nitrofurantoin: Uses, Dosage, Side Effects | Drugs.com
  7. Trimethoprim Uses, Side Effects & Warnings | Drugs.com

Further Reading

  1. Nitrofurantoin is as effective as other long-term antibiotics | NHIR
  2. Urinary-tract infections, Treatment summary | BNF – NICE
  3. Nitrofurantoin vs Trimethoprim Comparison | Drugs.com